Glyphosine by Michels at Barbara Davis Centre for Childhood Diabetes

A specific molecule that can prevent the development of type 1 diabetes in mice has a similar effect on human cells from diabetic patients, according to researchers at the University of Colorado School of Medicine.

http://www.ncbi.nlm.nih.gov/pubmed/22043012
http://news.bioscholar.com/2011/11/promising-new-compound-to-prevent-type-1-diabetes-identified.html

GABA by Prud’homme at St. Michael’s Hospital in Toronto

News coverage: http://fftimes.com/node/243716

Quotes:

A natural chemical generated by the same cells that produce insulin in the pancreas has been found to not only prevent Type 1 diabetes in mice but reverse the condition, according to a new study.
Dr. Qinghua Wang and Dr. Gerald Prud’homme of St. Michael’s Hospital in Toronto led a team of international researchers in the study. Findings were published yesterday in the journal Proceedings of the National Academy of Sciences.

Gene Therapy and interleukin-10 by Chan at Baylor

However, when the researchers combined the gene therapy with interleukin-10 into a single intravenous injection, the treatment showed a complete reversal of diabetes in half of the mice during more than 20 months' follow-up. Although the therapy did not reverse autoimmunity throughout the body, it protected the new beta cells from the local destructive effect of autoimmunity, Chan explained.


http://english.farsnews.com/newstext.php?nn=8904060488

Gene Therapy targeting 12-Lipoxygenase at Eastern Virginia Medical School's Strelitz Diabetes Center

Studies have shown that deleting the gene that produces 12-LO can stop Type 1 diabetes in mice. Studies of donated human beta cells have allowed the researchers to confirm that the enzyme is the cause of beta cell destruction from inflammation. "We've now confirmed that 12-LO is a relevant target in humans, particularly in the pancreas, and will help lead to new therapies," says the EVMS researchers. 

http://www.emaxhealth.com/1020/23/35409/targeting-newly-identified-enzyme-could-cure-type-1-diabetes.html

Journal of Clinical Endocrinology & Metabolism , doi:10.1210/jc.2009-1102

Sertoli cells by Fallarino at University of Perugia

Quote:

We report that isolated neonatal porcine Sertoli cells , administered alone in highly biocompatible microcapsules, led to diabetes prevention and reversion in the respective 88 and 81% of overtly diabetic (nonobese diabetic [NOD]) mice, with no need for additional beta cell or insulin therapy. The effect was associated with restoration of systemic immune tolerance and detection of functional pancreatic islets that consisted of glucose-responsive and insulin-secreting cells.

Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19822646
Paper: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768846/

Cord Blood by Zhao at University of Illinois at Chicago

 Zhao Y, Lin B, Darflinger R, Zhang Y, Holterman MJ, Skidgel RA: Human cord
blood stem cell-modulated regulatory T lymphocytes reverse the
autoimmune-caused type 1 diabetes in nonobese diabetic (NOD) mice. PLoS
ONE 2009, 4:e4226

Abstact: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0004226
Full paper: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0004226#

lisofylline and exendin-4 by Yang at University of Virginia

Quote:

in this study we combined lisofylline to suppress autoimmunity and exendin-4 to enhance β-cell proliferation for treating autoimmune-mediated diabetes in the non-obese diabetic (NOD) mouse model. We found that this combined therapy effectively reversed new-onset diabetes within a week of therapy, and even maintained euglycemia up to 145 days after treatment withdrawal. 

Abstract: http://www.sciencedirect.com/science/article/pii/S0006291X06007066