Intestinal Parasite Infection by Mishra and Gause at University of Medicine and Dentistry of New Jersey

Yes, they infected NOD mice with an intestinal parasite, and this prevented later development of type-1.  Here's the quote from the press release:

shows that a two-week infection with the intestinal worm H. polygyrus (cured using oral drugs) prompted T cells to produce the cytokines interleukin (IL)-4 and IL-10, which acted independently to provide lasting protection against TID in mice

Abstract: http://www.nature.com/mi/journal/vaop/ncurrent/full/mi201271a.html
News Article: http://www.sciencedaily.com/releases/2012/07/120719103244.htm

Macrophages by Harris at Karolinska Institutet

Quote from the abstract:

Clinical therapeutic efficacy was assessed after adoptive transfer in NOD T1D, and after a single transfer of M2r macrophages, >80% of treated NOD mice were protected against T1D for at least 3 months, even when transfer was conducted just prior to clinical onset.

Quote from the news article:

At the end of the follow-up period only 25% of the mice receiving the cytokine-treated macrophages had developed Type 1 diabetes, while 83% of the control groups had become sick. 

"The cell therapy was initiated just 2 weeks before mice developed clinical diabetes", says Dr Harris. "At this stage few insulin-producing beta cells remain in the pancreas, yet we were able to protect these so that the mice never developed diabetes. Such a successful late-stage intervention has never previously been reported and is a significant result of our study. At the time of their clinical Type 1 diabetes diagnosis, most human individuals have already lost most of their insulin-producing beta cells."

News: http://bulletin.sciencebusiness.net/news/75792/Karolinska-researchers-prevent-mice-from-developing-diabetes
Abstract: http://diabetes.diabetesjournals.org/content/early/2012/06/20/db11-1635.abstract

Stem Cells (hESCs) by Rezania and Kieffer at University of British Columbia and BetaLogics

I'm not sure I should count this as a "cured in mice".  Basically the researchers took mice that had a compromised immune system, and then made them diabetic by poisoning their pancreas, and then cured them by implanting human embryonic stem cells (hESCs).  I think this proves that they know the recipe to turn hESCs into functional beta cells (a huge advance in itself), but it is not a cure for real type-1 diabetes, because the autoimmune attack would still kill off the new beta cells.  The mice used in this experiment did not have autoimmune (type-1) diabetes.

From the abstract:

As graft-derived insulin levels increased over time, diabetic mice were weaned from exogenous insulin and human C-peptide secretion was eventually regulated by meal and glucose challenges.

Abstract: http://diabetes.diabetesjournals.org/content/early/2012/06/25/db11-1711.abstract
Press release: http://www.eurekalert.org/pub_releases/2012-06/uobc-scc062512.php
News article: http://www.dailyrx.com/news-article/type-1-diabetic-mice-no-longer-need-insulin-treatment-after-stem-cell-transplantation-1

Non-Depleting Antibodies by Yi and Tisch at University of North Carolina

From the news article:

In some of the recently diagnosed NOD mice, blood sugar levels returned to normal within 48 hours of treatment. Within five days, about 80 percent of the animals had undergone diabetes remission, reversal of clinical diabetes. 

"The protective effect is very rapid, and once established, is long-term," [Tisch] said. "We followed the animals in excess of 400 days after the two antibody treatments, and the majority remained free of diabetes. And although the antibodies are cleared from within the animals in 2-3 weeks after treatment, the protective effect persists." The study showed that beta cells in the NOD mice had been rescued from ongoing autoimmune destruction.

I was asked if this is new concept or not.  Basically, I think that, in science, everything is based on work done before, so deciding that something is "new" or not usually involves arguing about the definition of "new", and is a waste of time.  Everything has some new parts and some old parts.

However, I will say that work in non-depleting antibodies targeting CD4 and CD8 to cure or prevent type-1 diabetes has been going on for about 20 years.  (Pubmed references from 1992, so the research actually has gone on longer than that.)  So from that point of view, I don't think this basic approach is completely novel, but I'm hoping these researchers are using a different antibody than has been used in the past, and that they will be more successful in humans than previous attempts.

Sources:
http://www.sciencedaily.com/releases/2012/07/120706013709.htm
http://diabetes.diabetesjournals.org/content/early/2012/06/25/db12-0098

Much older stuff:
http://onlinelibrary.wiley.com/doi/10.1002/eji.1830220735/abstract
http://www.freepatentsonline.com/5670150.html

bone marrow and cell grow factors by Zeng at University of Florida

Quote:

a new combination therapy that reverses established Type 1 diabetes in mice. ... The two-step regimen involves bone marrow transplantation and substances that promote the growth of cells that produce insulin, the sugar-regulating hormone that is missing in people who have Type 1 diabetes.

Source: http://news.ufl.edu/2012/05/09/diabetes-reversal/
News article: http://www.bloomberg.com/news/2012-05-09/immune-cell-therapy-cures-diabetic-mice-researchers-find.html

Hyperbaric Oxygen by Pileggi at Diabetes Research Institute

Hyperbaric Oxygen treatment is basically putting people in a chamber with extra oxygen at higher pressure. In these experiments, animals were put in 100% oxygen at twice normal atmospheric pressure.

Quotes from the abstract:

Spontaneous diabetes incidence reduced from 85% in controls to 65% in  [hyperbaric oxygen treatment]  (P = 0.01). ... Cyclophosphamide-induced diabetes onset was reduced from 85.3% in controls to 48% after [hyperbaric oxygen treatment] (P < 0.005) and paralleled by lower insulitis. 

Quote from the news article:

In mice, the treatment caused changes in the immune system's response to newly developing diabetes, and reduced the risk of diabetes between 20 and 40 percent. In the mice that still developed diabetes, the hyperbaric therapy delayed disease progression, the investigators found.

News article: http://health.usnews.com/health-news/news/articles/2012/05/11/oxygen-therapy-slows-type-1-diabetes-in-mice-study-says
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22566533

proinsulin autoantigen, IL-10, and anti-CD3 by Mathieu at KU Leuven

Quote:

Our intervention effectively reverted diabetes in newly diagnosed diabetic NOD mice, with a success rate seldom approached in NOD mice,” the authors conclude. “The therapy allowed us to exploit lower doses of anti-CD3 (ideally to circumvent side effects and undesired reactions) in combination with other interventions to enhance therapeutic efficacy. In particular, our combination therapy using L. lactis expressing PINS and hIL10 and low-dose anti-CD3 preserved functional β cell mass, resolved severe insulitis

And here was another interesting tid-bit:

Interestingly, the team reports, there was no evidence that the L. lactis-anti-CD3 therapy actually triggered beta-cell proliferation. Rather, it seemed to enable regranulation or reactivation of beta cells that had been deactivated by diabetes-related immune inflammation. This suggests that the treatment may only work when there are enough potentially functional beta cells present to start with.

News coverage:
http://www.genengnews.com/gen-news-highlights/engineered-gut-bacteria-reverse-type-1-diabetes-in-experimental-mice/81246608/
Abstract: http://www.jci.org/articles/view/60530#sd

This mouse cure is combining three different treatments and two different delivery systems, so they have got a lot going on.

The anti-CD3 drug is given by injection, so that is standard.  However the proinsulin and the IL-10 is given by genetically modifying a bacteria, and then putting that bacteria in the mouse's gut.  This avoids the problem where the proteins in proinsulin and IL-10 are digested.  Instead they are generated by bacteria right where they are absorbed into the blood stream.

As for the treatments, it's "one of everything":

• Anti-CD3 is an immune system modulator (This drug has been tried extensively in the past, and looked good early on, but failed in phase-III human tests.)
• IL-10 lowers inflammation and lowers the action of part of the immune system called NK cells. (NK "natural killer" cells is part of the immune system, but completely different than the T cells and B cells that most anti-type-1 treatments target.  Obviously, inflammation is an approach which just became popular in the last 4-7 years, and has not panned out as yet.)
• Pro-insulin is an antigen specific attempt to train the immune system not to self attack.  (Like giving peanut proteins to people allergic to peanuts.)