However, when the researchers combined the gene therapy with interleukin-10 into a single intravenous injection, the treatment showed a complete reversal of diabetes in half of the mice during more than 20 months' follow-up. Although the therapy did not reverse autoimmunity throughout the body, it protected the new beta cells from the local destructive effect of autoimmunity, Chan explained.
http://english.farsnews.com/newstext.php?nn=8904060488
Sunday, June 27, 2010
Sunday, May 2, 2010
Gene Therapy targeting 12-Lipoxygenase at Eastern Virginia Medical School's Strelitz Diabetes Center
Studies have shown that deleting the gene that produces 12-LO can stop Type 1 diabetes in mice. Studies of donated human beta cells have allowed the researchers to confirm that the enzyme is the cause of beta cell destruction from inflammation. "We've now confirmed that 12-LO is a relevant target in humans, particularly in the pancreas, and will help lead to new therapies," says the EVMS researchers.
http://www.emaxhealth.com/1020/23/35409/targeting-newly-identified-enzyme-could-cure-type-1-diabetes.html
Journal of Clinical Endocrinology & Metabolism , doi:10.1210/jc.2009-1102
http://www.emaxhealth.com/1020/23/35409/targeting-newly-identified-enzyme-could-cure-type-1-diabetes.html
Journal of Clinical Endocrinology & Metabolism , doi:10.1210/jc.2009-1102
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