Type-1 Diabetes Cured In Mice: January 2012

Monday, January 30, 2012

anti-CD98hc by Lian at University of Tokushima

Paper Title: Manipulation of CD98 resolves type 1 diabetes in nonobese diabetic mice.

Quote from the Abstract:

Injection of the anti-CD98hc [monoclonal antibody] completely prevented the onset of cyclophosphamide-induced diabetes in NOD mice. Treatment of diabetic NOD mice with anti-CD98hc reversed the diabetic state to normal levels, .... Furthermore, treatment of diabetic NOD mice with CD98hc small interfering RNA resolved T1D. These data indicate that strategies targeting CD98hc might have clinical application for treating T1D

Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22291182

Saturday, January 28, 2012

Protein and Nanoparticle by Santamaria at Parvus

Quote:

Parvus, which is basically Santamaria, Coggins and Jord Cowan and two of them still have day jobs has spent the last 18 months testing the treatment on mice.
With 70 per cent to 80 per cent of the animals permanently free of diabetes after receiving the injections, according to Coggins, the company is now looking to raise $30 million to move to clinical trials.
Even the 20 to 30 per cent of mice who relapse see the disease disappear after another round of treatment, Coggins said.

News article: http://www.calgaryherald.com/touch/story.html?id=6064209

Sunday, January 1, 2012

Catenarin by Shen at Taiwan

Quote from Abstract:

Overall, the data demonstrate the preventive effect and molecular mechanism of action of catenarin on T1D, suggesting its novel use as a prophylactic agent in T1D.

Abstract: http://www.hindawi.com/journals/ecam/2012/982396/abs/
Full paper: http://downloads.hindawi.com/journals/ecam/2012/982396.pdf

What is in This Blog?

My goal, starting in 2012, (and including as much before then as possible) is to have a blog entry for every treatment reported to have cured type-1 diabetes in NOD mice, or any other animal.

Each entry in this blog is a report of one cure for type-1 diabetes in an animal.

Each title will be of the form TREATMENT by DOCTOR at RESEARCH INSTITUTION.

Each entry will have the date the cure was reported, one or more links to news reports, press releases, or research papers, and maybe a paragraph on the cure.

But I don't plan to put much analysis or discussion in these blog entries. I'm leaving comments open for now, but I really only want comments to note when one of these cures moves to a later stage of research.

Why This Blog?

This blog exists because of frustration. My frustration at constantly hearing that type-1 diabetes had been cured in mice (again), but never hearing that it was cured in people.

My way of dealing with this frustration is to try to keep track of the number of times people cure type-1 diabetes in animals. After all the first step to understanding something, is to catalog it. You can think of this blog as raw material for future research into type-1 cures in mice.

At the very least, this blog will help the entire type-1 diabetes research community keep track of how many mice cures are developed each year, what happens to them, and how long it takes to happen. I hope that the data found will fuel other types of "research into research" on type-1 diabetes.

About Animal Experiments

Things to remember about experiments on animals (sometimes called "pre-clinical trials"):

* Most research is not successful.

* New research done in animals is at least 10-15 years away from general availability to people.

* Most research done in animals never progresses to people.

* Although NOD mice are generally considered the best animal model of type-1 diabetes, they differ from people with type-1 in many ways.

* Recently we have cured type-1 diabetes in animals many times each year, but so far, none of those cures has turned into a cure for people.