Monday, October 26, 2009

Sertoli cells by Fallarino at University of Perugia

We report that isolated neonatal porcine Sertoli cells , administered alone in highly biocompatible microcapsules, led to diabetes prevention and reversion in the respective 88 and 81% of overtly diabetic (nonobese diabetic [NOD]) mice, with no need for additional beta cell or insulin therapy. The effect was associated with restoration of systemic immune tolerance and detection of functional pancreatic islets that consisted of glucose-responsive and insulin-secreting cells.


Monday, January 19, 2009

Cord Blood by Zhao at University of Illinois at Chicago

 Zhao Y, Lin B, Darflinger R, Zhang Y, Holterman MJ, Skidgel RA: Human cord
blood stem cell-modulated regulatory T lymphocytes reverse the
autoimmune-caused type 1 diabetes in nonobese diabetic (NOD) mice. PLoS
ONE 2009, 4:e4226

Full paper: