We report that isolated neonatal porcine Sertoli cells , administered alone in highly biocompatible microcapsules, led to diabetes prevention and reversion in the respective 88 and 81% of overtly diabetic (nonobese diabetic [NOD]) mice, with no need for additional beta cell or insulin therapy. The effect was associated with restoration of systemic immune tolerance and detection of functional pancreatic islets that consisted of glucose-responsive and insulin-secreting cells.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19822646
Paper: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768846/
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