Wednesday, June 27, 2012

Stem Cells (hESCs) by Rezania and Kieffer at University of British Columbia and BetaLogics

I'm not sure I should count this as a "cured in mice".  Basically the researchers took mice that had a compromised immune system, and then made them diabetic by poisoning their pancreas, and then cured them by implanting human embryonic stem cells (hESCs).  I think this proves that they know the recipe to turn hESCs into functional beta cells (a huge advance in itself), but it is not a cure for real type-1 diabetes, because the autoimmune attack would still kill off the new beta cells.  The mice used in this experiment did not have autoimmune (type-1) diabetes.

From the abstract:
As graft-derived insulin levels increased over time, diabetic mice were weaned from exogenous insulin and human C-peptide secretion was eventually regulated by meal and glucose challenges.

Press release:
News article:

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