Type-1 Diabetes Cured In Mice: Ectopic PDX-1 expression in liver ameliorates type 1 diabetes.

Friday, September 21, 2012

Ectopic PDX-1 expression in liver ameliorates type 1 diabetes.

Using the model of cyclophosphamide-accelerated diabetes in non-obese diabetic (CAD-NOD) mice, we report that recombinant adenovirus mediated PDX-1 gene therapy, ameliorates hyperglycemia in CAD-NOD mice. Our data demonstrate that 43% of the overtly diabetic CAD-NOD mice treated with Ad-CMV-PDX-1 became normoglycemic and maintained a stable body weight.

http://www.ncbi.nlm.nih.gov/pubmed/17383157

http://www.deepdyve.com/lp/elsevier/ectopic-pdx-1-expression-in-liver-ameliorates-type-1-diabetes-YQBPZV2yBC

Newer:
http://www.biomedreports.com/2012061597242/using-a-diabetes-patients-own-liver-cells-as-a-novel-source-of-insulin.html

Quotes:

A novel approach to this problem is currently being pursued by a small biotech company named Orgenesis, which initiated its approach by asking the following question: What if a diabetes patient's own cells-extracted from his or her own mature tissue-could be made to produce insulin, secreting the compound automatically when needed? This particular variety of cell therapy is a form of what has been dubbed "autologous cell replacement."

Orgenesis has successfully tested its technology in mice, rats and pigs, and is working toward initiating clinical trials in humans.

1 comment:

Rachel L.November 2, 2012 at 8:04 AM
Joshua, Have you heard anything about whether or not the immune system will have a continued attack on these new liver-derived insulin producing cells? The cell transplant theory seems best to me (of all possible cures), but the immune attack has to also stop in order for them to last. Thoughts? - Rachel L. (Type 1, age 33 at onset).
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What is in This Blog?

My goal, starting in 2012, (and including as much before then as possible) is to have a blog entry for every treatment reported to have cured type-1 diabetes in NOD mice, or any other animal.

Each entry in this blog is a report of one cure for type-1 diabetes in an animal.

Each title will be of the form TREATMENT by DOCTOR at RESEARCH INSTITUTION.

Each entry will have the date the cure was reported, one or more links to news reports, press releases, or research papers, and maybe a paragraph on the cure.

But I don't plan to put much analysis or discussion in these blog entries. I'm leaving comments open for now, but I really only want comments to note when one of these cures moves to a later stage of research.

Why This Blog?

This blog exists because of frustration. My frustration at constantly hearing that type-1 diabetes had been cured in mice (again), but never hearing that it was cured in people.

My way of dealing with this frustration is to try to keep track of the number of times people cure type-1 diabetes in animals. After all the first step to understanding something, is to catalog it. You can think of this blog as raw material for future research into type-1 cures in mice.

At the very least, this blog will help the entire type-1 diabetes research community keep track of how many mice cures are developed each year, what happens to them, and how long it takes to happen. I hope that the data found will fuel other types of "research into research" on type-1 diabetes.

About Animal Experiments

Things to remember about experiments on animals (sometimes called "pre-clinical trials"):

* Most research is not successful.

* New research done in animals is at least 10-15 years away from general availability to people.

* Most research done in animals never progresses to people.

* Although NOD mice are generally considered the best animal model of type-1 diabetes, they differ from people with type-1 in many ways.

* Recently we have cured type-1 diabetes in animals many times each year, but so far, none of those cures has turned into a cure for people.