Friday, September 21, 2012

Ectopic PDX-1 expression in liver ameliorates type 1 diabetes.

Using the model of cyclophosphamide-accelerated diabetes in non-obese diabetic (CAD-NOD) mice, we report that recombinant adenovirus mediated PDX-1 gene therapy, ameliorates hyperglycemia in CAD-NOD mice. Our data demonstrate that 43% of the overtly diabetic CAD-NOD mice treated with Ad-CMV-PDX-1 became normoglycemic and maintained a stable body weight.



A novel approach to this problem is currently being pursued by a small biotech company named Orgenesis, which initiated its approach by asking the following question: What if a diabetes patient's own cells-extracted from his or her own mature tissue-could be made to produce insulin, secreting the compound automatically when needed? This particular variety of cell therapy is a form of what has been dubbed "autologous cell replacement."

Orgenesis has successfully tested its technology in mice, rats and pigs, and is working toward initiating clinical trials in humans.   

1 comment:

  1. Joshua, Have you heard anything about whether or not the immune system will have a continued attack on these new liver-derived insulin producing cells? The cell transplant theory seems best to me (of all possible cures), but the immune attack has to also stop in order for them to last. Thoughts? - Rachel L. (Type 1, age 33 at onset).