Wednesday, January 9, 2013

Intestinal microbes by Danska at Hospital for Sick Children and the University of Toronto


By exposing female mice to the gut bacteria of a healthy adult male, researchers were able to prevent the females from developing type 1 diabetes, an autoimmune disorder. ... the treatment changed the levels of testosterone in female mice, which typically develop type 1 diabetes at a higher rate than their male counterparts.

Abstract: http://www.sciencemag.org/content/early/2013/01/16/science.1233521.abstract

Microbial exposures and sex hormones exert potent effects on autoimmune diseases, many of which are more prevalent in women. Here, we demonstrate a direct interaction between sex hormones and early life microbial exposures on the control of autoimmunity in the non-obese diabetic (NOD) mouse model of type 1 diabetes (T1D). Colonization by commensal microbes elevated serum testosterone and protected NOD males from T1D. Transfer of gut microbiota from adult males to immature females altered the recipient's microbiota, resulting in elevated testosterone and metabolomic changes, reduced islet inflammation and autoantibody production, and robust T1D protection. These effects were dependent on androgen receptor activity. Thus, the commensal microbial community alters sex hormone levels and regulates autoimmune disease fate in individuals with high genetic risk.

2 comments:

  1. Cured in dogs
    http://www.uab.es/servlet/Satellite/latest-news/news-detail/uab-researchers-cure-type-1-diabetes-in-dogs-1096476786473.html?noticiaid=1345652365690

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  2. Vertical Pharmacy Say's : The NOD female mice used in the experiment normally have a 90% likelihood of developing type 1 diabetes. By transferring bacteria from the intestines of adult male mice to young female NOD mice, this likelihood was reduced to 25%.

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