Saturday, March 2, 2013

anti-CD20 and anti-CD3 by Hu and Wen at Yale


Combination treatment with anti-CD20 and oral anti-CD3 prevents and reverses autoimmune diabetes

Abstract: Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease, although B cells also play an important role in T1D development. Both T cell- and B cell-directed immunotherapies have shown efficacy in the prevention and reversal of T1D. However, whether the combined strategy of targeting both T and B cells could further improve the therapeutic efficacy remains to be explored. Herein we show that the combined treatment with intravenous anti-human CD20 (hCD20) and oral anti-CD3 significantly delayed diabetes development in pre-diabetic hCD20 transgenic NOD mice. More importantly, the combined treatment reversed diabetes in more than 60% of mice newly diagnosed with diabetes. Further mechanistic studies demonstrated that the addition of oral anti-CD3 to the B cell depletion therapy synergistically enhanced the suppressive function of Treg. Interestingly, the oral anti-CD3 treatment induced a fraction of IL-10-producing CD4 T cells in the small intestine through IL-10 and IL-27-producing dendritic cells. Thus, our findings demonstrated that combining anti-CD20 and oral anti-CD3 is superior to anti-CD20 monotherapy for restoring normoglycemia in diabetic NOD mice, providing important preclinical evidence for the optimization of B cell-directed therapy for type 1 diabetes.

3 comments:

  1. ForNatural Diabetes Cure Click On The Above Link

    To Get Rid Of Diabetes Click On The Given Link

    To Know How TO Cure Diabetes Click OnThe Link

    To Cure Diabetes Naturally Click On These Links

    ReplyDelete
  2. Hello Do you need cure to Diabetes Type 1? Or Type 2? Hepatitis B, C, A, What are you waiting for? Contact Dr. Oraede on dr.oraedespellhome@hotmail.com or call +2349038604218, I know sure well that he will cure any type of disease, he cured my Hepatitis B, He cure any type of disease with his Miracle Oil and his Spell, His Miracle Oil costs 1,500USD, while his Spell Cost 2,000USD I was cured with only 1,500USD, Health is Wealth, 1,500USD cannot not stop you from having your precious life back again, contact him ASAP.......... dr.oraedespellhome@hotmail.com or dr.oraedespellhome@gmail.com

    ReplyDelete